A Generalisation Signal Need Not Be a Model-Selection Signal

Model selection in computational biology often relies on validation data drawn from the training regime, even when deployment lies outside it. When validation no longer preserves which model is best, a natural alternative is to rank candidates using properties of the trained network itself. We test this idea using a novel, forward-only proxy motivated by the norm of the Hessian, alongside common Hessian measures, across molecular property, protein fitness, and drug-response tasks. Contrary to our hypothesis, geometry does not become more useful as validation spearman correlation deteriorates: augmenting validation helps some shifts but significantly harms others. More surprisingly, the proxy still correlates with generalisation gap even when Hessian trace and top-eigenvalue relationships are weak or reversed, yet this signal does not reliably identify the deployment-best model. A curvature bound need not preserve cross-model rankings, and low geometric scores can even favour collapsed predictors. Thus, a generalisation signal need not be a model-selection signal.