When Valid Evidence Goes Unused in Oncology Agents
Yoonjin Cho ⋅ Hansol Park ⋅ Won-Chul Lee
Abstract
Rejecting an ineligible oncology citation can leave an evidence inventory unfinished even when eligible alternatives remain available. We study this failure under record-specific molecular, disease, and origin conditions, separating evidence exposure, valid submission, and inventory recall. With one model and constructed rejected proposals, a fixed-exposure study supplies two eligible alternatives in every ten-record payload, yet diagnostic repair ends in abstention in 53/64 co-alteration trajectories. A follow-up using a common clarified prompt compares fresh answering with supplied rejection context on the same cases and candidates: fresh answering yields 54/64 valid inventories versus 43/64 for diagnostic repair, a difference of +17.2 percentage points ($95\%$ paired variant-cluster interval [2.8, 33.3]). Reframing the proposal and feedback as user review material does not consistently restore fresh yield. Separately, a post hoc replay on saved search paths raises inventory recall from $60.3\%$ to $67.2\%$ through deterministic serialization of acquired eligible records. These findings support evaluating recovery after rejection, preserving the eligible inventory, and assessing biological interpretation as distinct workflow objectives.
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