Learning from multi-view data is important in many applications, such as image classification and annotation. In this paper, we present a large-margin learning framework to discover a predictive latent subspace representation shared by multiple views. Our approach is based on an undirected latent space Markov network that fulfills a weak conditional independence assumption that multi-view observations and response variables are independent given a set of latent variables. We provide efficient inference and parameter estimation methods for the latent subspace model. Finally, we demonstrate the advantages of large-margin learning on real video and web image data for discovering predictive latent representations and improving the performance on image classification, annotation and retrieval.