We present the Copula Bayesian Network model for representing multivariate continuous distributions. Our approach builds on a novel copula-based parameterization of a conditional density that, joined with a graph that encodes independencies, offers great flexibility in modeling high-dimensional densities, while maintaining control over the form of the univariate marginals. We demonstrate the advantage of our framework for generalization over standard Bayesian networks as well as tree structured copula models for varied real-life domains that are of substantially higher dimension than those typically considered in the copula literature.