Abstract: Text-to-image diffusion models benefit artists with high-quality image generation. Yet their stochastic nature hinders artists from creating consistent images of the same subject. Existing methods try to tackle this challenge and generate consistent content in various ways. However, they either depend on external restricted data or require expensive tuning of the diffusion model. For this issue, we propose a novel one-shot tuning paradigm, termed OneActor. It efficiently performs consistent subject generation solely driven by prompts via a learned semantic guidance to bypass the laborious backbone tuning. We lead the way to formalize the objective of consistent subject generation from a clustering perspective, and thus design a cluster-conditioned model. To mitigate the overfitting challenge shared by one-shot tuning pipelines, we augment the tuning with auxiliary samples and devise two inference strategies: semantic interpolation and cluster guidance. These techniques are later verified to significantly improve the generation quality. Comprehensive experiments show that our method outperforms a variety of baselines with satisfactory subject consistency, superior prompt conformity as well as high image quality. Our method is capable of multi-subject generation and compatible with popular diffusion extensions. Besides, we achieve a $4\times$ faster tuning speed than tuning-based baselines and, if desired, avoid increasing the inference time. Furthermore, our method can be naturally utilized to pre-train a consistent subject generation network from scratch, which will implement this research task into more practical applications. (Project page: https://johnneywang.github.io/OneActor-webpage/)