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In a world where rapid innovation fuels our greatest ambitions, systems and AI have found themselves in a dynamic and transformative partnership. The systems community has worked tirelessly in the background, building the foundation that enabled AI’s meteoric rise. But now, AI’s exponential progress threatens to outpace the very systems supporting it. At this critical juncture, we propose a bold “marriage”—one that allows systems and AI to co-evolve in ways that push each beyond its current boundaries.

In this keynote, we will examine the role of systems in accelerating AI advancements, the strains AI’s unprecedented growth places on current infrastructures, and the emerging ways AI can reciprocate by transforming the systems landscape. Through systems thinking and core principles, we will outline the grand challenges that arise from this union, envisioning a future where systems and AI reshape each other, charting a path forward that calls on the AI community to foster a future of symbiotic growth.