Abstract: In this work we study how the stimulus distribution influences the optimal coding of an individual neuron. Closed-form solutions to the optimal sigmoidal tuning curve are provided for a neuron obeying Poisson statistics under a given stimulus distribution. We consider a variety of optimality criteria, including maximizing discriminability, maximizing mutual information and minimizing estimation error under a general $L_p$ norm. We generalize the Cramer-Rao lower bound and show how the $L_p$ loss can be written as a functional of the Fisher Information in the asymptotic limit, by proving the moment convergence of certain functions of Poisson random variables. In this manner, we show how the optimal tuning curve depends upon the loss function, and the equivalence of maximizing mutual information with minimizing $L_p$ loss in the limit as $p$ goes to zero.