A two day workshop will span topics from signal processing and musical structure to the cognition of music and sound. In the first day the workshop will provide a forum for cutting edge research addressing the fundamental challenges of modeling the structure of music and analysing its effect on the brain. It will also be a venue for interaction between the machine learning and the neuroscience/brain imaging communities to discuss the broader questions related to modeling the dynamics of brain activity. During the second day the workshop will focus on the modeling of sound, music perception and cognition. These have the potential to provide, with the crucial role of machine learning, a break-through in various areas of music technology, in particular: Music Information Retrieval (MIR), expressive music synthesis, interactive music making, and sound design.