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OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology

Cheng Jiang · Asadur Chowdury · Xinhai Hou · Akhil Kondepudi · Christian Freudiger · Kyle Conway · Sandra Camelo-Piragua · Daniel Orringer · Honglak Lee · Todd Hollon

Hall J (level 1) #1019

Keywords: [ Vision transformer ] [ contrastive learning ] [ Computer Vision ] [ convolutional neural network ] [ Stimulated Raman Histology ] [ Representation Learning ]


Accurate intraoperative diagnosis is essential for providing safe and effective care during brain tumor surgery. Our standard-of-care diagnostic methods are time, resource, and labor intensive, which restricts access to optimal surgical treatments. To address these limitations, we propose an alternative workflow that combines stimulated Raman histology (SRH), a rapid optical imaging method, with deep learning-based automated interpretation of SRH images for intraoperative brain tumor diagnosis and real-time surgical decision support. Here, we present OpenSRH, the first public dataset of clinical SRH images from 300+ brain tumors patients and 1300+ unique whole slide optical images. OpenSRH contains data from the most common brain tumors diagnoses, full pathologic annotations, whole slide tumor segmentations, raw and processed optical imaging data for end-to-end model development and validation. We provide a framework for patch-based whole slide SRH classification and inference using weak (i.e. patient-level) diagnostic labels. Finally, we benchmark two computer vision tasks: multi-class histologic brain tumor classification and patch-based contrastive representation learning. We hope OpenSRH will facilitate the clinical translation of rapid optical imaging and real-time ML-based surgical decision support in order to improve the access, safety, and efficacy of cancer surgery in the era of precision medicine.

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