Schistosomiasis is a neglected disease affecting almost every region of the world, with its endemicity mainly felt in sub-Saharan Africa. A mathematical modelof Schistosomiasis integrating heterogeneous host transmission pathways is thus formulated and analyzed to investigate the impact of the disease on the human pop ulation. Mathematical analyses are presented, including establishing the existence and uniqueness of solutions, computation of the model equilibria, and the basic reproduction number (R0). Our numerical findings suggest that reducing the snail population will directly reduce Schistosomiasis transmission within the humanpopulation and thus lead to its eradication