Abstract: Human hands possess remarkable dexterity and have long served as a source of inspiration for robotic manipulation. In this work, we propose a human $\textbf{H}$and-$\textbf{In}$formed visual representation learning framework to solve difficult $\textbf{Dex}$terous manipulation tasks ($\textbf{H-InDex}$) with reinforcement learning. Our framework consists of three stages: $\textit{(i)}$ pre-training representations with 3D human hand pose estimation, $\textit{(ii)}$ offline adapting representations with self-supervised keypoint detection, and $\textit{(iii)}$ reinforcement learning with exponential moving average BatchNorm. The last two stages only modify $0.36$% parameters of the pre-trained representation in total, ensuring the knowledge from pre-training is maintained to the full extent. We empirically study $\textbf{12}$ challenging dexterous manipulation tasks and find that $\textbf{H-InDex}$ largely surpasses strong baseline methods and the recent visual foundation models for motor control. Code and videos are available at https://yanjieze.com/H-InDex .