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Learning Absorption Rates in Glucose-Insulin Dynamics from Meal Covariates
Ke Alexander Wang · Matthew Levine · Jiaxin Shi · Emily Fox

Fri Dec 02 09:00 AM -- 09:30 AM (PST) @
Event URL: https://openreview.net/forum?id=cbn7xvCCq6e »

Traditional models of glucose-insulin dynamics rely on heuristic parameterizations chosen to fit observations within a laboratory setting. However, these models cannot describe glucose dynamics in daily life. One source of failure is in their descriptions of glucose absorption rates after meal events. A meal's macronutritional content has nuanced effects on the absorption profile, which is difficult to model mechanistically. In this paper, we propose to learn the effects of macronutrition content from glucose-insulin data and meal covariates. Given macronutrition information and meal times, we use a neural network to predict an individual's glucose absorption rate. We use this neural rate function as the control function in a differential equation of glucose dynamics, enabling end-to-end training. On simulated data, our approach is able to closely approximate true absorption rates, resulting in better forecast than heuristic parameterizations, despite only observing glucose, insulin, and macronutritional information. Our work readily generalizes to meal events with higher-dimensional covariates, such as images, setting the stage for glucose dynamics models that are personalized to each individual's daily life.

Author Information

Ke Alexander Wang (Stanford University)
Matthew Levine (California Institute of Technology)
Matthew Levine

5th year graduate student in computing and mathematical sciences at Caltech. I am interested in developing novel methods within the intersections of dynamical systems, machine learning, and data assimilation, and have most often applied these methods to biomedical contexts, including modeling and prediction of the glucose-insulin system.

Jiaxin Shi (Stanford University)
Emily Fox (Stanford University)

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