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Equivariant Transformers for Neural Network based Molecular Potentials
Philipp Thölke · Gianni De Fabritiis

The prediction of quantum mechanical properties is historically plagued by a trade-off between accuracy and speed. Machine learning potentials have previously shown great success in this domain, reaching increasingly better accuracy while maintaining computational efficiency comparable with classical force fields. In this work we propose a novel equivariant Transformer architecture, outperforming state-of-the-art on MD17 and ANI-1. Through an extensive attention weight analysis, we gain valuable insights into the black box predictor and show differences in the learned representation of conformers versus conformations sampled from molecular dynamics or normal modes. Furthermore, we highlight the importance of datasets including off-equilibrium conformations for the evaluation of molecular potentials.

Author Information

Philipp Thölke (Universitat Pompeu Fabra)
Gianni De Fabritiis (University Pompeu Fabra)

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