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The process of manually searching for relevant instances in, and extracting information from, clinical databases underpin a multitude of clinical tasks. Such tasks include disease diagnosis, clinical trial recruitment, and continuing medical education. This manual search-and-extract process, however, has been hampered by the growth of large-scale clinical databases and the increased prevalence of unlabelled instances. To address this challenge, we propose a supervised contrastive learning framework, CROCS, where representations of cardiac signals associated with a set of patient-specific attributes (e.g., disease class, sex, age) are attracted to learnable embeddings entitled clinical prototypes. We exploit such prototypes for both the clustering and retrieval of unlabelled cardiac signals based on multiple patient attributes. We show that CROCS outperforms the state-of-the-art method, DTC, when clustering and also retrieves relevant cardiac signals from a large database. We also show that clinical prototypes adopt a semantically meaningful arrangement based on patient attributes and thus confer a high degree of interpretability.
Author Information
Dani Kiyasseh (Caltech)
Tingting Zhu (University of Oxford)
David Clifton (University of Oxford)
Professor of Clinical Machine Learning Department of Engineering Science University of Oxford
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