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Poster
Closing the loop in medical decision support by understanding clinical decision-making: A case study on organ transplantation
Yuchao Qin · Fergus Imrie · Alihan Hüyük · Daniel Jarrett · alexander gimson · Mihaela van der Schaar

Thu Dec 09 08:30 AM -- 10:00 AM (PST) @
in Poster Session 6 »

Significant effort has been placed on developing decision support tools to improve patient care. However, drivers of real-world clinical decisions in complex medical scenarios are not yet well-understood, resulting in substantial gaps between these tools and practical applications. In light of this, we highlight that more attention on understanding clinical decision-making is required both to elucidate current clinical practices and to enable effective human-machine interactions. This is imperative in high-stakes scenarios with scarce available resources. Using organ transplantation as a case study, we formalize the desiderata of methods for understanding clinical decision-making. We show that most existing machine learning methods are insufficient to meet these requirements and propose iTransplant, a novel data-driven framework to learn the factors affecting decisions on organ offers in an instance-wise fashion directly from clinical data, as a possible solution. Through experiments on real-world liver transplantation data from OPTN, we demonstrate the use of iTransplant to: (1) discover which criteria are most important to clinicians for organ offer acceptance; (2) identify patient-specific organ preferences of clinicians allowing automatic patient stratification; and (3) explore variations in transplantation practices between different transplant centers. Finally, we emphasize that the insights gained by iTransplant can be used to inform the development of future decision support tools.

Keywords: Machine Learning · Generative Model

Author Information

Yuchao Qin (University of Cambridge)
Fergus Imrie (University of California, Los Angeles)
Alihan Hüyük (University of Cambridge)
Daniel Jarrett (University of Cambridge)
alexander gimson (Cambridge University Hospitals)
Mihaela van der Schaar (University of Cambridge)

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