Timezone: »
Pamela Silver, Debora Marks, and Chang Liu in conversation.
Author Information
Pamela Silver (Harvard Medical School)
Debora Marks (Harvard University)
Debora is a mathematician and computational biologist with a track record of using novel algorithms and statistics to successfully address unsolved biological problems. She has a passion for interpreting genetic variation in a way that impacts biomedical applications. During her PhD, she quantified the pan-genomic scope of microRNA targeting - the combinatorial regulation of protein expression and co-discovered the first microRNA in a virus. As a postdoc she made a breakthrough in the classic, unsolved problem of ab initio 3D structure prediction of proteins using undirected graphical probability models for evolutionary sequences. She has developed this approach to determine functional interactions, biomolecular structures, including the 3D structure of RNA and RNA-protein complexes and the conformational ensembles of apparently disordered proteins. Her new lab at Harvard is interested in developing methods in deep learning to address a wide range of biological challenges including designing drug affinity libraries for large numbers of human genes, predicting epistasis in antibiotic resistance, the effects of genetic variation on human disease etiology and drug response and sequence design for biosynthetic applications.
Chang Liu (UC Irvine)
Professor Liu’s research is in the fields of synthetic biology, chemical biology, and directed evolution. He is particularly interested in engineering specialized genetic systems for rapid mutation and evolution of genes in vivo. These systems can then be widely applied for the engineering, discovery, and understanding of biological function.
Possu Huang (Stanford University)
More from the Same Authors
-
2022 : How can we use natural evolution and genetic experiments to design protein functions? »
Ada Shaw · June Shin · Debora Marks -
2022 : TranceptEVE: Combining Family-specific and Family-agnostic Models of Protein Sequences for Improved Fitness Prediction »
Pascal Notin · Lodevicus van Niekerk · Aaron Kollasch · Daniel Ritter · Yarin Gal · Debora Marks -
2022 : Kernelized Stein Discrepancies for Biological Sequences »
Alan Amin · Eli Weinstein · Debora Marks -
2022 : scPerturb: Information Resource for Harmonized Single-Cell Perturbation Data »
Tessa Green · Stefan Peidli · Ciyue Shen · Torsten Gross · Joseph Min · Samuele Garda · Jake Taylor-King · Debora Marks · Augustin Luna · Nils Blüthgen · Chris Sander -
2022 : Designing and Evolving Neuron-Specific Proteases »
Han Spinner · Colin Hemez · Julia McCreary · David Liu · Debora Marks -
2022 Workshop: Learning Meaningful Representations of Life »
Elizabeth Wood · Adji Bousso Dieng · Aleksandrina Goeva · Alex X Lu · Anshul Kundaje · Chang Liu · Debora Marks · Ed Boyden · Eli N Weinstein · Lorin Crawford · Mor Nitzan · Rebecca Boiarsky · Romain Lopez · Tamara Broderick · Ray Jones · Wouter Boomsma · Yixin Wang · Stephen Ra -
2022 Poster: Non-identifiability and the Blessings of Misspecification in Models of Molecular Fitness »
Eli Weinstein · Alan Amin · Jonathan Frazer · Debora Marks -
2021 Workshop: Learning Meaningful Representations of Life (LMRL) »
Elizabeth Wood · Adji Bousso Dieng · Aleksandrina Goeva · Anshul Kundaje · Barbara Engelhardt · Chang Liu · David Van Valen · Debora Marks · Edward Boyden · Eli N Weinstein · Lorin Crawford · Mor Nitzan · Romain Lopez · Tamara Broderick · Ray Jones · Wouter Boomsma · Yixin Wang -
2020 : Contributed Talk - ProGen: Language Modeling for Protein Generation »
Ali Madani · Bryan McCann · Nikhil Naik · · Possu Huang · Richard Socher -
2020 : Invited Talk - Possu Huang »
Possu Huang -
2020 : Chang Liu »
Chang Liu -
2020 Workshop: Learning Meaningful Representations of Life (LMRL.org) »
Elizabeth Wood · Debora Marks · Ray Jones · Adji Bousso Dieng · Alan Aspuru-Guzik · Anshul Kundaje · Barbara Engelhardt · Chang Liu · Edward Boyden · Kresten Lindorff-Larsen · Mor Nitzan · Smita Krishnaswamy · Wouter Boomsma · Yixin Wang · David Van Valen · Orr Ashenberg -
2019 Workshop: Learning Meaningful Representations of Life »
Elizabeth Wood · Yakir Reshef · Jonathan Bloom · Jasper Snoek · Barbara Engelhardt · Scott Linderman · Suchi Saria · Alexander Wiltschko · Casey Greene · Chang Liu · Kresten Lindorff-Larsen · Debora Marks -
2018 : Invited Talk Session 2 »
Debora Marks · Olexandr Isayev · Tess Smidt · Nathaniel Thomas -
2018 : TBC 4 »
Debora Marks -
2018 Poster: Generative modeling for protein structures »
Namrata Anand · Possu Huang