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Sparse convolutional coding for neuronal assembly detection
Sven Peter · Elke Kirschbaum · Martin Both · Lee Campbell · Brandon Harvey · Conor Heins · Daniel Durstewitz · Ferran Diego · Fred Hamprecht

Tue Dec 05 06:30 PM -- 10:30 PM (PST) @ Pacific Ballroom #71

Cell assemblies, originally proposed by Donald Hebb (1949), are subsets of neurons firing in a temporally coordinated way that gives rise to repeated motifs supposed to underly neural representations and information processing. Although Hebb's original proposal dates back many decades, the detection of assemblies and their role in coding is still an open and current research topic, partly because simultaneous recordings from large populations of neurons became feasible only relatively recently. Most current and easy-to-apply computational techniques focus on the identification of strictly synchronously spiking neurons. In this paper we propose a new algorithm, based on sparse convolutional coding, for detecting recurrent motifs of arbitrary structure up to a given length. Testing of our algorithm on synthetically generated datasets shows that it outperforms established methods and accurately identifies the temporal structure of embedded assemblies, even when these contain overlapping neurons or when strong background noise is present. Moreover, exploratory analysis of experimental datasets from hippocampal slices and cortical neuron cultures have provided promising results.

Author Information

Sven Peter (University Heidelberg)
Elke Kirschbaum (HCI/IWR, Heidelberg University)
Martin Both (Institute for Physiology and Pathophysiology Heidelberg University)
Lee Campbell (Intramural Research Program, National Institute on Drug Abuse)
Brandon Harvey (Intramural Research Program, National Institute on Drug Abuse)
Conor Heins (Intramural Research Program, National Institute on Drug Abuse)
Daniel Durstewitz (CIMH Heidelberg University)
Ferran Diego (Bosch)
Fred Hamprecht (Heidelberg University)

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