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Identification of Recurrent Patterns in the Activation of Brain Networks
Firdaus Janoos · Weichang Li · Niranjan Subrahmanya · Istvan Morocz · William Wells

Thu Dec 06 02:00 PM -- 12:00 AM (PST) @ Harrah’s Special Events Center 2nd Floor #None

Identifying patterns from the neuroimaging recordings of brain activity related to the unobservable psychological or mental state of an individual can be treated as a unsupervised pattern recognition problem. The main challenges, however, for such an analysis of fMRI data are: a) defining a physiologically meaningful feature-space for representing the spatial patterns across time; b) dealing with the high-dimensionality of the data; and c) robustness to the various artifacts and confounds in the fMRI time-series. In this paper, we present a network-aware feature-space to represent the states of a general network, that enables comparing and clustering such states in a manner that is a) meaningful in terms of the network connectivity structure; b)computationally efficient; c) low-dimensional; and d) relatively robust to structured and random noise artifacts. This feature-space is obtained from a spherical relaxation of the transportation distance metric which measures the cost of transporting ``mass'' over the network to transform one function into another. Through theoretical and empirical assessments, we demonstrate the accuracy and efficiency of the approximation, especially for large problems. While the application presented here is for identifying distinct brain activity patterns from fMRI, this feature-space can be applied to the problem of identifying recurring patterns and detecting outliers in measurements on many different types of networks, including sensor, control and social networks.

Author Information

Firdaus Janoos (Two Sigma Investments)
Weichang Li (ExxonMobil Research)
Niranjan Subrahmanya (ExxonMobil Research)
Istvan Morocz (Harvard Medical School)
William Wells (Harvard Medical School)

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