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Regulator Discovery from Gene Expression Time Series of Malaria Parasites: a Hierachical Approach
José Miguel Hernández-Lobato · Tjeerd M Dijkstra · Tom Heskes

Tue Dec 04 10:30 AM -- 10:40 AM (PST) @

We introduce a hierarchical Bayesian model for the discovery of putative regulators from gene expression data only. The hierarchy incorporates the knowledge that there are just a few regulators that by themselves only regulate a handful of genes. This is implemented through a so-called spike-and-slab prior, a mixture of Gaussians with different widths, with mixing weights from a hierarchical Bernoulli model. For efficient inference we implemented expectation propagation. Running the model on a malaria parasite data set, we found four genes with significant homology to transcription factors in an amoebe, one RNA regulator and three genes of unknown function (out of the top ten genes considered).

Author Information

José Miguel Hernández-Lobato (University of Cambridge)
Tjeerd M Dijkstra (Radboud University Nijmegen)
Tom Heskes (Radboud University Nijmegen)

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